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1. Nutr Hosp. 2011 Dec;26(6):1322-7.

Association of nutritional status, plasma, albumin levels and pulmonary function
in cystic fibrosis.

Souza Dos Santos Simon MI, Drehmer M, de Abreu E Silva FA, Hoffmann A, Druck
Ricachinewsky C, de Fonseca Andrade Procianoy E, Scattolin I, Saldanha Menna
Barreto S.

Serviço de Nutrição e Dietética, Centro de Estudos em Alimentação e Nutrição,
Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

Background & aims: Malnutrition is related with pulmonary disease. The aim was to
analyze the association of lung function respectively to nutritional status,
identified pulmonary pathogens and socioeconomic condition of patients attending
a pediatric CF reference center. Methods: Cross-sectional study performed with CF
patients aged 6 to 18 years attending a CF-Center in southern Brazil. Nutritional
status, plasma albumin level and pulmonary bacterial colonization were assessed.
The outcome studied was forced expiratory volume in 1 second (FEV1). Results:
Eighty-five patients were included in this study. FEV1 was significantly
associated with body mass index (BMI) percentiles, plasma albumin level and
methicillin resistant Staphylococcus aureus (MRSA) pulmonary colonization.
Regression analysis showed that BMI below the 10th percentile was associated with
a 25.58% drop in FEV1, and plasma albumin levels equal to or lower than 4.1 mg/dL
was associated with 18.6% FEV1 reduction. FEV1 was 14.4% lower in the MRSA
infected patients. Plasma albumin of 4.25 mg/dL predicted FEV1 of 60% with 76.9%
sensitivity and 72.2% specificity, and 85.7% accuracy. The socioeconomic status
was not association with pulmonary function. Conclusion: BMI below the 10th
percentile and albumin below 4.1 mg/dL were predictors of low FEV1. Chronic MRSA
infection was associated with lower FEV1. Longitudinal studies may better
complement these results.

PMID: 22411378 [PubMed - in process]