albumin - publications

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1. Indian J Physiol Pharmacol. 2011 Apr-Jun;55(2):128-38.

Association of albumin-globulin ratio with sympathovagal imbalance in
pregnancy-induced hypertension.

Pal GK, Shyma P, Habeebullah S, Shyjus P, Pal P, Nanda N.

Department of Physiology, Jawaharlal Institute of Medical Education and Research
(JIPMER), Puducherry--605 006. gopalpravati@sify.com

The early prediction of pregnancy-induced hypertension (PIH) is based on the
demonstration of increased sympathetic activity in early part of pregnancy.
However, the mechanisms that increase sympathetic activity in PIH have not yet
been fully elucidated. Therefore, in the present study we have investigated the
link of albumin-globulin ratio (AGR) to sympathovagal imbalance in PIH patients.
Spectral analysis of HRV was performed in three groups of subjects (Group I:
normal pregnant women; Group II: pregnant women with risk factors for PIH, but
did not develop PIH; Group III: pregnant women with risk factors and developed
PIH) and their biochemical parameters including AGR were recorded. It was
observed that LF-HF ratio, the most sensitive indicator of sympathovagal balance
was significantly high (P < 0.01) since early pregnancy in group III compared to
other groups, which was considerably correlated with AGR in group III (PIH
subjects). It was suggested that alteration in AGR could have direct contribution
to the sympathovagal imbalance that plays a critical role in the genesis of PIH.

PMID: 22319893 [PubMed - in process]