albumin - publications

1. Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Jan;33(1):32-6.

[Association between urinary albumin-to-creatinine ratio and prehypertension].

[Article in Chinese]

Zhang Q, Peng H, Ding JS, Xu YY, Chao XQ, Tian HG, Zhang YH.

Department of Epidemiology, School of Public Health, Medical College of Soochow
University, Suzhou 215123, China; Center for Disease Control and Prevention of
Jinchang District, Suzhou.

OBJECTIVE: This study was operated to investigate the association between urinary
albumin-to-creatinine ratio (UACR) and physical situations as hypertension and
prehypertension among women.
METHODS: Blood pressure, height, weight and waist circumference were measured and
factors such as cigarette smoking, alcohol intake, family history of
hypertension, were investigated. Blood glucose and lipid, serum uric acid,
urinary albumin and urinary creatinine were tested on 1796 women aged ≥ 30 years
living in the Jinchang district of Suzhou. Associations between UACR and
hypertension as well as prehypertension were analyzed, by using ordinal
multinomial logistic regression models.
RESULTS: The mean levels of UACR were 15.54 (7.67, 32.53), 9.01 (5.45, 18.06),
7.13 (4.60, 12.50) mg/g and the rates of higher UACR were 27.57%, 13.42%, 9.61%
in hypertensive, pre-hypertensive and normotensive subjects, respectively, with
significant differences noticed among the three groups (P < 0.05). The average
systolic blood pressure/diastolic blood pressure appeared to be 125.3/80.9,
128.8/82.7, 130.8/84.0 and 135.1/85.9 mm Hg for participants with UACR in the
first, second, third and fourth quartile, respectively. The risks of
prehypertension or hypertension increased with increasing UACR levels.
Dose-response relationship was seen between UACR and risks of prehypertension or
hypertension. Multivariable adjusted odds ratios (95%CI) of prehypertension or
hypertension in the upper quartiles of UACR were 1.32 (1.02, 1.70), 1.72 (1.32,
2.24), and 2.37 (1.80, 3.11), respectively, when compared with the lowest
quartile.
CONCLUSION: Elevated UACR was associated with both hypertension and
prehypertension among women.

PMID: 22575106 [PubMed - in process]