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1. Clin Exp Dermatol. 2012 May 21. doi: 10.1111/j.1365-2230.2012.04384.x. [Epub
ahead of print]

Assessment of ischaemia-modified albumin level in patients with psoriasis.

Ozdemir M, Kiyici A, Balevi A, Mevlitoğlu I, Peru C.

Departments of Dermatology and Internal Medicine, School of Medicine, Bezmialem
Vakif University, Istanbul, Turkey Department of Biochemistry, Selçuklu School of
Medicine, Selçuk University, Konya, Turkey Department of Dermatology, Meram
School of Medicine, Selçuk University, Konya, Turkey.

Background.  Ischaemia-modified albumin (IMA) is increased in diseases associated
with oxidative stress, as detected using the albumin cobalt-binding test.
Oxidative stress plays an important role in the development of psoriasis. Aim. 
To investigate circulating IMA levels in patients with psoriasis and its
association with the disease characteristics. Methods.  Serum IMA and albumin
concentrations were evaluated in 26 patients with psoriasis and 26 healthy
controls matched for age, gender and body mass index. Levels of albumin, IMA and
adjusted IMA were compared between the groups. Results.  IMA and adjusted IMA
were significantly higher in patients with psoriasis [0.55 ± 0.04 and 0.54 ± 0.05
absorbance units (ABSU), respectively] than in healthy controls (0.38 ± 0.04 and
0.38 ± 0.05 ABSU, respectively). The two groups had similar albumin levels, but
there was a negative correlation between IMA and albumin levels in patients with
psoriasis. IMA did not correlate with any disease characteristics. Conclusions. 
IMA levels are higher in patients with psoriasis than in healthy controls. IMA
might be produced through an adaptive response to chronic hypoxia and oxidative
stress, which might play a role in the systemic inflammation seen in psoriasis.

© The Author(s). CED © 2012 British Association of Dermatologists.

PMID: 22607558 [PubMed - as supplied by publisher]