albumin - publications

Predict more albumin - ligand interactions now!


1. J Agric Food Chem. 2012 May 18. [Epub ahead of print]

Analysis of the structural and immunological stability of 2S albumin, nonspecific
lipid transfer protein, and profilin allergens from mustard seeds.

Sirvent S, Palomares O, Cuesta-Herranz J, Villalba M, Rodriguez R.

This work investigates the resistance to proteolysis and heating of the yellow
mustard (Sinapis alba L.) allergens Sin a 1 (2S albumin), Sin a 3 (nonspecific
lipid transfer protein, LTP) and Sin a 4 (profilin) to explain their potential
capability to induce primary sensitization at the gastrointestinal level. Sin a 1
and Sin a 3 resisted the gastric digestion showing no reduction of the IgE
reactivity. Intestinal digestion of Sin a 1 and Sin a 3 produced a limited
proteolysis but retained significant IgE-binding reactivity. Sin a 1 was stable
after heating, and although Sin a 3 was modified, most of its structure was
recovered after cooling back. These two allergens would be therefore able to
sensitize by ingestion. Sin a 4 was completely digested by gastric treatment and
its conformational structure markedly modified at 85 ÂșC. Thus, this allergen can
be described as a non-sensitizing mustard allergen.

PMID: 22594937 [PubMed - as supplied by publisher]