albumin - publications

Predict more albumin - ligand interactions now!


1. Anat Cell Biol. 2012 Mar;45(1):47-52. Epub 2012 Mar 31.

Activated microglial cells synthesize and secrete AGE-albumin.

Byun K, Bayarsaikhan E, Kim D, Son M, Hong J, Jeong GB, Paek SH, Won MH, Lee B.

Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute,
Gachon University, Incheon, Korea.

A holy grail of curing neurodegenerative diseases is to identify the main causes
and mechanisms underlying neuronal death. Many studies have sought to identify
these targets in a wide variety of ways, but a more important task is to identify
critical molecular targets and their origins. Potential molecular targets include
advanced glycation end products (AGEs) that can promote neuronal cell death,
thereby contributing to neurodegenerative disorders such as Alzheimer disease or
Parkinson disease. In this study, we showed that AGE-albumin (glycated albumin)
is synthesized in microglial cells and secreted in the human brain. Our results
provide new insight into which microglial cells can promote the receptor for
AGE-mediated neuronal cell death, eventually leading to neurodegenerative
diseases.

PMID: 22536551 [PubMed - in process]