albumin - publications

Predict more albumin - ligand interactions now!

1. J Crit Care. 2012 Apr 18. [Epub ahead of print]

A method for estimation of plasma albumin concentration from the buffering
properties of whole blood.

Rees SE, Diemer T, Kristensen SR.

Center for Model-based Medical Decision Support, Institute for Health Science and
Technology, Aalborg University, 9220 Aalborg, Denmark.

PURPOSE: Hypoalbuminemia is strongly associated with poor clinical outcome.
Albumin is usually measured at the central laboratory rather than point of care,
but in principle, information exists in the buffering properties of whole blood
to estimate plasma albumin concentration from point of care measurements of
acid-base and oxygenation status. This article presents and evaluates a new
method for doing so. MATERIALS AND METHODS: The mathematical method for
estimating plasma albumin concentration is described. To evaluate the method at
numerous albumin concentrations, blood from 19 healthy subjects was diluted at 3
different levels giving 57 data sets. Calculated and measured plasma albumin
concentrations were compared using correlation coefficient (r(2)), regression
line, and Bland-Altman bias and limits of agreement. RESULTS: Albumin levels
covered the clinically interesting range from 8.8 to 53.3 g/L. Calculated and
measured plasma albumin concentrations compared well with r(2) = 0.9, a
regression line of albumin-calculated = 1.05 × albumin-measured - 2.25, a small
average bias between measured and calculated values of 0.7 g/L, and Bland-Altman
limits of agreement of 10 g/L. CONCLUSIONS: This new method may be a valuable
tool in screening and monitoring plasma albumin concentration in acutely ill
patients, from measurements taken at the point of care.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID: 22520487 [PubMed - as supplied by publisher]