albumin - publications

Predict more albumin - ligand interactions now!


1. Clin Exp Nephrol. 2012 Feb 23. [Epub ahead of print]

A lower level of reduced albumin induces serious cardiovascular incidence among
peritoneal dialysis patients.

Terawaki H, Matsuyama Y, Matsuo N, Ogura M, Mitome J, Hamaguchi A, Terada T, Era
S, Hosoya T.

Division of Kidney and Hypertension, The Jikei University School of Medicine,
Tokyo, Japan, terawaki@jikei.ac.jp.

BACKGROUND: Human serum albumin is composed of human mercaptoalbumin (HMA) with
cysteine residues having reducing powers and of oxidized human
non-mercaptoalbumin. Previously, we reported that a lower HMA level is closely
related to serious cardiovascular disease (CVD) incidence and mortality among
hemodialysis patients. However, the relationship between HMA level and CVD
incidence among peritoneal dialysis (PD) patients is unclear. METHODS: We
measured the redox state of human serum albumin using high-performance liquid
chromatography in 30 continuous ambulatory PD patients. The association between
HMA and incidental CVD events was evaluated. RESULTS: Eight patients experienced
symptomatic CVD events (5 patients died) at the 5-year follow-up. The
concentration and fraction of HMA (cHMA and f(HMA), respectively) showed
significantly lower values in patients with CVD than those without CVD (cHMA
1.58 ± 0.39 and 2.16 ± 0.43 g/dL, f(HMA) 48.9 ± 5.4 and 56.4 ± 8.6%,
respectively). Multiple forward stepwise regression analysis using cHMA and
f(HMA) as the criterion variables was performed, and C-reactive protein and
hemoglobin were adopted as significant explanatory variables in the former
equation, whereas urea nitrogen was adopted in the latter equation. Multiple
logistic regression analysis revealed that cHMA is a statistically, and f(HMA) is
a marginally significant explanatory variable of CVD incidence (p = 0.0369,
R = -0.260 and p = 0.0580, R = -0.214, respectively). CONCLUSIONS: Lower HMA
level, which might be caused by chronic inflammation, anemia and accumulation of
dialyzable uremic toxin(s), is closely related to serious CVD incidence among PD
patients.

PMID: 22358613 [PubMed - as supplied by publisher]