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A Comparative Interaction between Copper Ions with Alzheimer's β Amyloid Peptide and Human Serum Albumin.


Bioinorg Chem Appl. 2012;2012:208641


Authors: Behbehani GR, Barzegar L, Mohebbian M, Saboury AA


Abstract

The interaction of Cu(2+) with the first 16 residues of the Alzheimer's amyliod β peptide, Aβ(1-16), and human serum albumin (HSA) were studied in vitro by isothermal titration calorimetry at pH 7.2 and 310 K in aqueous solution. The solvation parameters recovered from the extended solvation model indicate that HSA is involved in the transport of copper ion. Complexes between Aβ(1-16) and copper ions have been proposed to be an aberrant interaction in the development of Alzheimer's disease, where Cu(2+) is involved in Aβ(1-16) aggregation. The indexes of stability indicate that HSA removed Cu(2+) from Aβ(1-16), rapidly, decreased Cu-induced aggregation of Aβ(1-16), and reduced the toxicity of Aβ(1-16) + Cu(2+) significantly.

PMID: 22844264 [PubMed - as supplied by publisher]