albumin - publications

Predict more albumin - ligand interactions now!

1. Clin Exp Hypertens. 2012 Apr 25. [Epub ahead of print]

A Bedtime Dose of ARB Was Better than a Morning Dose in Improving Baroreflex
Sensitivity and Urinary Albumin Excretion-The J-TOP Study.

Eguchi K, Shimizu M, Hoshide S, Shimada K, Kario K.

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical
University School of Medicine , Tochigi , Japan.

The hypothesis that the bedtime dosing of angiotensin receptor blocker (ARB) is
superior to morning dose in improving baroreflex sensitivity (BRS) and urinary
albumin/creatinine ratio (UACR) was tested in this study. Baroreflex sensitivity
was measured at baseline and at 6th month (N = 109) and was found to increase in
the bedtime-dose group (P = .004), but not in the morning-dose group. The
correlations between the change in BRS and the change in UACR were insignificant
in the morning-dose group (r = 0.17, P = .26), but were significant in the
bedtime-dose group (r = -0.29, P = .04). In conclusion, the improvement of BRS
could be one of the mechanisms by which bedtime dosing of ARB confers renal

PMID: 22533496 [PubMed - as supplied by publisher]